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Ethisterone

Cat. No. M5628
Ethisterone Structure
Synonym:

Pregneninolone; 17α-Ethynyltestosterone

Size Price Availability Quantity
100mg USD 67.5  USD75 In stock
500mg USD 103.5  USD115 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ethisterone is a progestogen hormone being considered to treat prostate cancer.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 312.45
Formula C21H28O2
CAS Number 434-03-7
Purity >98%
Solubility 0.05 mg/mL in DMSO
Storage at -20°C
References

Click chemistry inspired highly facile synthesis of triazolyl ethisterone glycoconjugates.
Kumar D, et al. Steroids. 2014 Feb;80:71-9. PMID: 24316164.

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  Catalog
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Keywords: Ethisterone, Pregneninolone; 17α-Ethynyltestosterone supplier, Estrogen Receptor, inhibitors

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