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Ethinyl Estradiol

Cat. No. M3392
Ethinyl Estradiol Structure
Synonym:

17α-Ethynylestradiol; Ethynylestradiol

Size Price Availability Quantity
100mg USD 60  USD60 In stock
500mg USD 95  USD95 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Ethynyl estradiol is an orally bio-active estrogen used in almost all modern formulations of combined oral contraceptive pills. EE is hormonally effective by activating the estrogen receptor and thus is an estrogen. It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 296.4
Formula C20H24O2
CAS Number 57-63-6
Purity >98%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

[1] Amy J Voedisch, et al. Oestrogen component of COCs: have we finally found a replacement for ethinyl estradiol?

[2] Amy L Lee. Segesterone Acetate and Ethinyl Estradiol Vaginal Ring (Annovera) for Contraception

[3] F Trmollieres. Oral combined contraception: is there any difference between ethinyl-estradiol and estradiol?

[4] Andrea J Rapkin, et al. Drospirenone/ethinyl estradiol

[5] J W Goldzieher, et al. Pharmacokinetics of ethinyl estradiol and mestranol

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ethinyl Estradiol, 17α-Ethynylestradiol; Ethynylestradiol supplier, Estrogen Receptor, inhibitors

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