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Cat. No. M7552
ETH2120 Structure

Sodium ionophore III

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10mg USD 120 4-7 Days
50mg USD 330 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Preincubation of the cells with the Na+ ionophore sodium ionophore III not only stimulated caffeate reduction, but completely abolished ATP synthesis. Addition of sodium ionophore III to cells in the steady state of caffeate reduction immediately dissipated the intracellular ATP level. Lactate-sulfate grown cells are insensitive to the Na+ ionophore, ETH2120. Sodium ionophore III ligand is a very effective receptor for the Eu3+ and Am3+ cations and can be considered as a potential extraction agent for nuclear iste treatment.

Cell Experiment
Cell lines Desulfovibrio alaskensis
Preparation method The protonophore 3,3,4,5-tetrachlorosalicylanilide (TCS, 5 µM or 20 µM), or the sodium-specific ionophore N,N,N′,N′-Tetracyclohexyl-1,2-phenylenedioxydiacetamide (ETH2120, 20 µM) were added to media to test their effects on growth.
Concentrations 20 µM
Incubation time 24 h
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 552.79
Formula C34H52N2O4
CAS Number 81686-22-8
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C

Reaction engineering analysis of the autotrophic energy metabolism of Clostridium aceticum.
Mayer A, et al. FEMS Microbiol Lett. 2017 Dec 1;364(22). PMID: 29069379.

The role of Rnf in ion gradient formation in Desulfovibrio alaskensis.
Wang L, et al. PeerJ. 2016 Apr 14;4:e1919. PMID: 27114876.

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Abmole Inhibitor Catalog 2017

Keywords: ETH2120, Sodium ionophore III supplier, Sodium Channel, inhibitors

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