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Estropipate

Cat. No. M5627
Estropipate Structure
Synonym:

Piperazine estrone sulfate; Estrone sulfate piperazine salt

Size Price Availability Quantity
10mg USD 60  USD60 In stock
50mg USD 110  USD110 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 436.56
Formula C22H22N2O5S
CAS Number 7280-37-7
Purity >98%
Solubility 36 mg/mL in DMSO
Storage at -20°C
References

[1] Bagdade JD, et al, J Clin Endocrinol Metab. Effects of estropipate treatment on plasma lipids and lipoprotein lipid composition in postmenopausal women.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Estropipate, Piperazine estrone sulfate; Estrone sulfate piperazine salt supplier, Estrogen Receptor, inhibitors

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