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Eptapirone

Cat. No. M8932
Eptapirone Structure
Synonym:

F11440

Size Price Availability Quantity
5mg USD 350 In stock
10mg USD 500 In stock
50mg USD 1480 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

The affinity of Eptapirone (F11440) for 5-HT1A binding sites (pKi, 8.33) was higher than that of buspirone (pKi, 7.50), and somewhat lower than that of flesinoxan (pKi, 8.91). In vivo, Eptapirone (F11440) was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 345.4
Formula C16H23N7O2
CAS Number 179756-58-2
Purity >98%
Solubility DMSO: 5 mg/mL (Need ultrasonic)
Storage at -20°C
References

The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans.
Wilson SJ, et al. J Psychopharmacol. 2005 Nov;19(6):609-13. PMID: 16272182.

F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.
Koek W, et al. J Pharmacol Exp Ther. 1998 Oct;287(1):266-83. PMID: 9765347.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Eptapirone, F11440 supplier, 5-HT Receptor, inhibitors

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