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Epicoccamide

Cat. No. M22316
Epicoccamide Structure
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Biological Activity

Epicoccamide

Chemical Information
Molecular Weight 557.72
Formula C29H51NO9
CAS Number 606139-26-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tao Zhang, et al. Microb Cell Fact. Mining and characterization of the PKS-NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996

[2] Harwoko Harwoko, et al. Fitoterapia. Azacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079

[3] Sebastian Loscher, et al. Chemistry. Total synthesis and absolute configuration of epicoccamide D, a naturally occurring mannosylated 3-acyltetramic acid

[4] Hilaire V Kemami Wangun, et al. J Nat Prod. Epicoccamides B-D, glycosylated tetramic acid derivatives from an Epicoccum sp. associated with the tree fungus Pholiota squarrosa

[5] Anthony D Wright, et al. Org Biomol Chem. Epicoccamide, a novel secondary metabolite from a jellyfish-derived culture of Epicoccum purpurascens

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