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Cat. No. M5612
Emricasan Structure

IDN-6556, PF 03491390, PF-03491390

Size Price Availability Quantity
5mg USD 160 In stock
10mg USD 260 In stock
50mg USD 1000 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Emricasan is a potent irreversible pan-caspase inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 569.50
Formula C26H27F4N3O7
CAS Number 254750-02-2
Purity >99%
Solubility 100 mg/mL in DMSO
Storage at -20°C

Carcinogenicity assessment of the pan-caspase inhibitor, emricasan, in Tg.rasH2 mice.
Elbekai RH, et al. Regul Toxicol Pharmacol. 2015 Jul;72(2):169-78. PMID: 25896096.

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Abmole Inhibitor Catalog 2017

Keywords: Emricasan, IDN-6556, PF 03491390, PF-03491390 supplier, Caspase, inhibitors

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