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Embinin

Cat. No. M16825
Embinin Structure
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Biological Activity

Embinin

Chemical Information
CAS Number 52589-13-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hawraz Ibrahim M Amin, et al. Nat Prod Commun. Phytochemistry and Ethnopharmacology of Some Medicinal Plants Used in the Kurdistan Region of Iraq

[2] Benjamin R Clark, et al. J Agric Food Chem. Chemotaxonomy of Hawaiian Anthurium cultivars based on multivariate analysis of phenolic metabolites

[3] Benjamin R Clark, et al. Nat Prod Commun. Flavone C-glycosides from Anthurium andraeanum

[4] F K Friedman, et al. Pharmacology. Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase

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