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EMA400

Cat. No. M9040
EMA400 Structure
Synonym:

PD-126055

Size Price Availability
10mg USD 200 4-7 Days
50mg USD 650 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

EMA400 is a potent and highly selective AT2R antagonist. The angiotensin II type 2 (AT2) receptor is a target with promising data in rodent models of peripheral neuropathic pain.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 507.58
Formula C32H29NO5
CAS Number 152362-51-1
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

Small molecule angiotensin II type 2 receptor (AT₂R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats.
Smith MT, et al. Pain Med. 2013 May;14(5):692-705. PMID: 23489258.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EMA400, PD-126055 supplier, ACE, inhibitors

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