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Eluxadoline

Cat. No. M5067
Eluxadoline Structure
Synonym:

JNJ-27018966

Size Price Availability Quantity
2mg USD 220 In stock
5mg USD 340 In stock
10mg USD 480 In stock
50mg USD 1440 In stock
100mg USD 2100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Coadministration of a single 200?mg dose of eluxadoline with cyclosporine, and probenecid increased eluxadoline systemic exposure [AUC(0-inf) ] by 4.4- and 1.4-fold, respectively, whereas peak exposure (Cmax ) increased 6.2-fold and 1.3-fold, respectively. Cyclosporine had little effect on renal clearance (CLren ) of eluxadoline whereas probenecid reduced CLren by nearly 50%.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 569.65
Formula C32H35N5O5
CAS Number 864821-90-9
Purity >99%
Solubility 10Mm in DMSO
Storage at -20°C
References

Effect of uptake transporters OAT3 and OATP1B1 and efflux transporter MRP2 on the pharmacokinetics of eluxadoline.
Davenport JM,et.al. J Clin Pharmacol. 2015 May;534-42. PMID: 25491493.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Eluxadoline, JNJ-27018966 supplier, Opioid Receptor, inhibitors

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