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ELQ-300

Cat. No. M10502
ELQ-300 Structure
Synonym:

Endochin-like quinolone-300

Size Price Availability Quantity
5mg USD 340  USD340 In stock
10mg USD 530  USD530 In stock
25mg USD 950  USD950 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Elq-300 is an antimalarial drug available for biological research and is also an effective oral cytochrome BC1 complex (CYT BC1) reduction (Qi) site inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 475.84
Formula C24H17ClF3NO4
CAS Number 1354745-52-0
Purity >98.5%
Solubility DMSO 10 mg/mL
Storage at -20°C
References

[1] Marta G Silva, et al. Parasit Vectors . Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

[2] Allison M Stickles, et al. Antimicrob Agents Chemother . Atovaquone and ELQ-300 Combination Therapy as a Novel Dual-Site Cytochrome bc1 Inhibition Strategy for Malaria

[3] Allison M Stickles, et al. Antimicrob Agents Chemother . Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum

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Keywords: ELQ-300, Endochin-like quinolone-300 supplier, Anti-infection, inhibitors

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