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ELN484228 is a cell penetrant α-synuclein ligand that rescues of α-synuclein induced disruption of vesicle trafficking and dopaminergic neuronal loss and neurite retraction. ELN484228 reverses a-synuclein induced impairment of phagocytosis and protects dopaminergic neurons against the toxic effects of α-synuclein A53T over-expression.
| Molecular Weight | 251.28 |
| Formula | C12H10FNO2S |
| CAS Number | 312-63-0 |
| Form | Solid |
| Solubility (25°C) | DMSO ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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