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Eledoisin Related Peptide

Cat. No. M22251
Eledoisin Related Peptide Structure
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Biological Activity

Eledoisin Related Peptide

Chemical Information
Molecular Weight 706.94
Formula C34H58N8O6S
CAS Number 2990-43-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] I Spence, et al. Neuroscience. The effect of calcium ions on the responses to motoneurons to substance P and eledoisin-related peptide in the toad and rat spinal cord

[2] J L Henry, et al. Neuroscience. Effects of glutamate, substance P and eledoisin-related peptide on solitary tract neurones involved in respiration and respiratory reflexes

[3] A Saria, et al. Acta Otolaryngol Suppl. Control of vascular permeability and vascular smooth muscle in the respiratory tract by multiple neuropeptides

[4] L P Felpel, et al. J Auton Nerv Syst. Response of splanchnic-driven neurons to substance P and eledoisin-related peptide

[5] B Holstein, et al. Am J Physiol. Effects of tachykinins on gastric acid and pepsin secretion and on gastric outflow in the Atlantic cod, Gadus morhua

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