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(-)-Epigallocatechin gallate

Cat. No. M4208
(-)-Epigallocatechin gallate Structure
Synonym:

EGCG; Epigallocatechol Gallate

Size Price Availability Quantity
20mg USD 40 In stock
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Quality Control
Biological Activity

(-)-Epigallocatechin Gallate (EGCG) inhibits activation EGFR, HER2 and HER3 in the SW837 human colon cancer cell line. (-)-Epigallocatechin Gallate (10 μM) also inhibits cell growth, suppresses activation of EGFR, HER2, and HER3, and causes decrease in the levels of COX-2 and Bcl-xL proteins, and apoptosis after treatment for 96 h. In vivo, (-)-Epigallocatechin Gallate (5, 10, and 20 mg/kg, p.o.) inhibits the growth of orthotopic colorectal cancer cells in mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 458.37
Formula C22H18O11
CAS Number 989-51-5
Purity 99.57%
Solubility DMSO 20 mg/mL
Water 15 mg/mL
Storage at -20°C
References

Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines.
De Amicis F, et al. J Cell Physiol. 2013 Oct;228(10):2054-62. PMID: 23553645.

Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling.
Jin H, et al. Onco Targets Ther. 2013;6:145-53. PMID: 23525843.

Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells.
Tsang WP, et al. J Nutr Biochem. 2010 Feb;21(2):140-6. PMID: 19269153.

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Keywords: (-)-Epigallocatechin gallate, EGCG; Epigallocatechol Gallate supplier, EGFR/HER2, inhibitors

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