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Efloxate

Cat. No. M22438
Efloxate Structure
Size Price Availability Quantity
10mg USD 180  USD180 In stock
25mg USD 265  USD265 In stock
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Quality Control & Documentation
Biological Activity

Efloxate

Chemical Information
Molecular Weight 324.33
Formula C19H16O5
CAS Number 119-41-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tiziana Ginex, et al. Pharmaceuticals (Basel). Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods

[2] H A DEWAR, et al. Br Heart J. A clinical trial of penta-erythritol tetranitrate, a khellin derivative (recordil), and iproniazid in angina of effort

[3] A STRAUSAK, et al. Cardiologia (Basel). [Ethyl-7-hydroxyaceto-flavone (recordil) in the therapy of angina pectoris and its effects on hemodynamics and renal function]

[4] M Veronese, et al. Boll Chim Farm. [Mutagenesis of efloxate tested in vitro and in vivo]

[5] A M Tomasi, et al. Clin Ter. [Clinical research on the therapeutic efficacy and tolerance of long-acting efloxate in angina pectoris]

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Keywords: Efloxate supplier, inhibitors, activators

 
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