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ECBN HCL

Cat. No. M6132

ECBN HCL Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

ECBN biosynthesis cluster Ani in the genome of the echinocandin B producer strain A. nidulans NRRL 8112. ECBN belongs to lipopeptide antifungal antibiotic bearing five types of direct precursor amino acids including proline, ornithine, tyrosine, threonine, and leucine. ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 834.27
Formula C34H51N7O15.HCl
CAS Number 1029890-89-8
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Enhancement of Echinocandin B Production by a UV- and Microwave-Induced Mutant of Aspergillus nidulans with Precursor- and Biotin-Supplying Strategy.
Hu ZC, et al. Appl Biochem Biotechnol. 2016 Aug;179(7):1213-26. PMID: 27039401.

Efficient bioconversion of echinocandin B to its nucleus by overexpression of deacylase genes in different host strains.
Shao L, et al. Appl Environ Microbiol. 2013 Feb;79(4):1126-33. PMID: 23220968.

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Keywords: ECBN HCL supplier, inhibitors

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