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EBE-A22

Cat. No. M8905

All AbMole products are for research use only, cannot be used for human consumption.

EBE-A22 Structure
Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 140  USD140 In stock
25mg USD 280  USD280 In stock
50mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent.

Chemical Information
Molecular Weight 374.23
Formula C17H16BrN3O2
CAS Number 229476-53-3
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Grunt TW, et al. J Cell Physiol. Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.

[2] Goossens JF, et al. Biochemistry. DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.

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Keywords: EBE-A22 supplier, inhibitors, activators

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