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EBE-A22

Cat. No. M8905
EBE-A22 Structure
Size Price Availability Quantity
5mg USD 300 In stock
10mg USD 450 In stock
50mg USD 1050 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

EBE-A22 is a derivative of PD 153035. EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. EBE-A22 binds to DNA and behave as typical intercalating agents. EBE-A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 374.23
Formula C17H16BrN3O2
CAS Number 229476-53-3
Purity >98%
Solubility DMSO
Storage at -20°C
References

Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
Grunt TW, et al. J Cell Physiol. 2007 Jun;211(3):803-15. PMID: 17286282.

DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Goossens JF, et al. Biochemistry. 2001 Apr 17;40(15):4663-71. PMID: 11294633.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: EBE-A22 supplier, inhibitors

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