Free shipping on all orders over $ 500


Cat. No. M3764
DY131 Structure

GSK 9089

Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. Sox2-Cre:Errβ+/lox and Sox2-Cre:Errβlox/lox mice treated with the Errβ and Errγ agonist DY131 demonstrated increased corticotropin-releasing hormone (Crh) expression in the paraventricular nucleus of the hypothalamus, although corticosterone levels were not affected. Adrenal Cyp11b1 and Cyp11b2 mRNA were increased in pregnant WT mice treated with DY131. In this study,using RNA knockdown and transcriptional activation with DY131 (an ERRγ agonist), we clearly demonstrated that ERRγ promotes hormone production and cell fusion indicating that ERRγ is a key positive transcriptional factor involved in CT differentiation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 311.38
Formula C18H21N3O2
CAS Number 95167-41-2
Purity >98%
Solubility DMSO 100 mg/mL
Ethanol 10 mg/mL
Storage at -20°C

Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-γ activation.
Poidatz D, et al. Mol Hum Reprod. 2014 Nov 6. PMID: 25376642.

Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy.
Luo Y, et al. Mol Endocrinol. 2014 Jun;28(6):965-75. PMID: 24725083.

Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
Byerly MS, et al. BMC Physiol. 2013 Sep 22;13:10. PMID: 24053666.

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.
Wang Y, et al. ACS Chem Biol. 2012 Jun 15;7(6):1040-8. PMID: 22554036.

Related Estrogen Receptor Products

Relugolix, also known as TAK-385, is a luteinizing hormone-releasing hormone (LH-RH) receptor antagonist with an IC50 of 0.12 nM.

Elagolix sodium

Elagolix Soidum is a potent, selective, orally active, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with Kd value of 54 pM.


GDC-0810 (Brilanestrant, ARN-81) is an orally bioavailable selective estrogen receptor degrader (SERD) with IC50 of 0.7 nM.


Tamoxifen is a estrogen receptor partial agonist/antagonist.

GSK 4716

GSK 4716 is a selective agonist with estrogen-related receptors ERRβ and ERRγ.

Abmole Inhibitor Catalog 2017

Keywords: DY131, GSK 9089 supplier, Estrogen Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.