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DY131

Cat. No. M3764
DY131 Structure
Synonym:

GSK 9089

Size Price Availability Quantity
5mg USD 69.3  USD77 In stock
10mg USD 90  USD100 In stock
50mg USD 364.5  USD405 In stock
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Quality Control
Biological Activity

DY131 appears to inhibit Smo signaling through a common binding site shared by previously reported Smo agonists and antagonists. Sox2-Cre:Errβ+/lox and Sox2-Cre:Errβlox/lox mice treated with the Errβ and Errγ agonist DY131 demonstrated increased corticotropin-releasing hormone (Crh) expression in the paraventricular nucleus of the hypothalamus, although corticosterone levels were not affected. Adrenal Cyp11b1 and Cyp11b2 mRNA were increased in pregnant WT mice treated with DY131. In this study,using RNA knockdown and transcriptional activation with DY131 (an ERRγ agonist), we clearly demonstrated that ERRγ promotes hormone production and cell fusion indicating that ERRγ is a key positive transcriptional factor involved in CT differentiation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 311.38
Formula C18H21N3O2
CAS Number 95167-41-2
Purity 99.75%
Solubility DMSO 100 mg/mL
Ethanol 10 mg/mL
Storage at -20°C
References

Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-γ activation.
Poidatz D, et al. Mol Hum Reprod. 2014 Nov 6. PMID: 25376642.

Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy.
Luo Y, et al. Mol Endocrinol. 2014 Jun;28(6):965-75. PMID: 24725083.

Estrogen-related receptor β deficiency alters body composition and response to restraint stress.
Byerly MS, et al. BMC Physiol. 2013 Sep 22;13:10. PMID: 24053666.

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation.
Wang Y, et al. ACS Chem Biol. 2012 Jun 15;7(6):1040-8. PMID: 22554036.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: DY131, GSK 9089 supplier, Estrogen Receptor, inhibitors

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