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Drospirenone

Cat. No. M5599
Drospirenone Structure
Synonym:

ZK 3059

Size Price Availability Quantity
10mg USD 63  USD70 In stock
50mg USD 180  USD200 In stock
100mg USD 270  USD300 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Drospirenone is a synthetic progestin that is an analog to spironolactone.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 366.49
Formula C24H30O3
CAS Number 67392-87-4
Purity >98%
Solubility 73 mg/mL in DMSO
Storage at -20°C
References

Drospirenone-containing oral contraceptive pills and the risk of venous and arterial thrombosis: a systematic review.
Wu CQ, et al. BJOG. 2013 Jun;120(7):801-10. PMID: 23530659.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Drospirenone, ZK 3059 supplier, Estrogen Receptor, inhibitors

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