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Drospirenone

Cat. No. M5599
Drospirenone Structure
Synonym:

ZK 3059

Size Price Availability Quantity
10mg USD 70 In stock
50mg USD 200 In stock
100mg USD 300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Drospirenone is a synthetic progestin that is an analog to spironolactone.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 366.49
Formula C24H30O3
CAS Number 67392-87-4
Purity >98%
Solubility 73 mg/mL in DMSO
Storage at -20°C
References

Drospirenone-containing oral contraceptive pills and the risk of venous and arterial thrombosis: a systematic review.
Wu CQ, et al. BJOG. 2013 Jun;120(7):801-10. PMID: 23530659.

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  Catalog
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Keywords: Drospirenone, ZK 3059 supplier, Estrogen Receptor, inhibitors

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