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Doxazosin Mesylate

Cat. No. M5593
Doxazosin Mesylate Structure
Size Price Availability Quantity
50mg USD 80 In stock
100mg USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 547.58
Formula C23H25N5O5.CH4O3S
CAS Number 77883-43-3
Purity >99%
Solubility 15 mg/mL in DMSO
Storage at -20°C
References

Preparation and evaluation of sustained-release doxazosin mesylate pellets.
Ha JM, et al. Chem Pharm Bull (Tokyo). 2013;61(4):371-8. PMID: 23385960.

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  Catalog
Abmole Inhibitor Catalog 2017




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