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Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 189.64 |
| Formula | C8H11NO2.HCl |
| CAS Number | 62-31-7 |
| Purity | >98% |
| Solubility | 38 mg/mL in DMSO |
| Storage | at -20°C |
Protective and toxic roles of dopamine in Parkinson's disease.
Segura-Aguilar J, et al. J Neurochem. 2014 Jun;129(6):898-915. PMID: 24548101.
| Related Dopamine Receptor Products |
|---|
| Cariprazine
Cariprazine is a D2 and D3 receptor partial agonist, with high selectivity towards the D3 receptor. |
| PD-168077 maleate
PD-168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM), with > 400-fold and > 300-fold selectivity over D2 / D3 subtypes, respectively. |
| SCH23390
SCH23390 is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). |
| MPTP HCl
MPTP hcl is a compound to the neurotoxin MPP+ which causes permanent symptoms of Parkinson's disease. |
| SKF38393 HCl
SKF38393 HCl is a selective D1 dopamine receptor agonist with IC50 of 110 nM. |
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