DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.
| Molecular Weight | 564.67 |
| CAS Number | 157341-41-8 |
| Solubility (25°C) | DMSO 38.33 mg/mL |
| Storage | -20°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] K S Raghavan, et al. Degradation kinetics of DMP 777, an elastase inhibitor
[3] E H Manning, et al. Tamoxifen Acts as a Parietal Cell Protonophore
[5] Masako Ogawa, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777
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