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DMP 777

Cat. No. M14333
DMP 777 Structure
Synonym:

L-694458

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 564.67
Formula
CAS Number 157341-41-8
Purity >99%
Solubility DMSO 38.33 mg/mL
Storage -20°C, sealed
References

[1] Takahiro Shimizu, et al. Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation

[2] K S Raghavan, et al. Degradation kinetics of DMP 777, an elastase inhibitor

[3] E H Manning, et al. Tamoxifen Acts as a Parietal Cell Protonophore

[4] Haengdueng Jeong, et al. WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury

[5] Masako Ogawa, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777

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  Catalog
Abmole Inhibitor Catalog




Keywords: DMP 777, L-694458 supplier, Elastase, inhibitors

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