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Disulfiram

Cat. No. M3390
Disulfiram Structure
Synonym:

Tetraethylthiuram disulfide; TETD

Size Price Availability Quantity
500mg USD 80 In stock
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Quality Control
Biological Activity

Disulfiram is an agent used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram is also being studied as a treatment for cocaine dependence, as it prevents the breakdown of dopamine (a neurotransmitter whose release is stimulated by cocaine); the excess dopamine results in increased anxiety, higher blood pressure, restlessness and other unpleasant symptoms. Several studies have reported that it has anti-protozoal activity as well.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 296.54
Formula C10H20N2S4
CAS Number 97-77-8
Purity 99.67%
Solubility DMSO 50 mg/mL
Storage at -20°C
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  Catalog
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Keywords: Disulfiram, Tetraethylthiuram disulfide; TETD supplier, ALDH, inhibitors

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