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DIMBOA

Cat. No. M10463
DIMBOA Structure
Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 165  USD165 In stock
25mg USD 360  USD360 In stock
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Quality Control
Biological Activity

DIMBOA is a powerful antibiotic present in maize, wheat, and related grasses, possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 211.17
Formula C9H9NO5
CAS Number 15893-52-4
Purity 98.84%
Solubility DMSO 100 mg/mL
Storage at -20°C
References

[1] Karina Lucas Silva-Brandao, et al. Pest Manag Sci. Transcriptome differential co-expression reveals distinct molecular response of fall-armyworm strains to DIMBOA

[2] Michal Glensk, et al. Nat Prod Res. In vitro evaluation of the antioxidant and antimicrobial activity of DIMBOA [2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one]

[3] Hiroaki Sasai, et al. Biosci Biotechnol Biochem. Species-specific glucosylation of DIMBOA in larvae of the rice Armyworm

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