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Diisopropylammonium dichloroacetate (DIPA) was found to exert a significant and prolonged hypoglycemic effect in alloxan diabetic rats, but did not alter blood sugar levels of normal rats.It did not affect blood glycerol levels in either the diabetic or nondiabetic group.The selective hypoglycemic effect of DIPA is due, at least in part, to a suppression of fatty acid oxidation in diabetic muscle that results in a lowering of muscle citrate. The reduction in citrate levels reactivates PFK and promotes accelerated utilization of glucose.
| Molecular Weight | 230.16 |
| Formula | C6H15N.C2H2Cl2O2 |
| CAS Number | 660-27-5 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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