Dicycloamine is an anticholinergic compound, a chemical released by nerves that stimulate muscle by blocking acetylcholine receptors on smooth muscle, a type of muscle.
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Source | Neurobiol Dis (2015). Figure 6. Dicyclomine hydrochloride |
| Method | i.p. | |
| Cell Lines | C57BL/6mice | |
| Concentrations | 25 mg/kg | |
| Incubation Time | 30 min | |
| Results | Famotidine (50 mg/kg) significantly reduced three-paw dyskinesia, an effect mimicked by dicyclomine |
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Source | Neurobiol Dis (2015). Figure 5. Dicyclomine hydrochloride |
| Method | i.p. | |
| Cell Lines | C57BL/6mice | |
| Concentrations | 45 mg/kg | |
| Incubation Time | 120 min | |
| Results | Summing dyskinesia scores over the entire time frame of LID testing from 0 to 120 min revealed that the higher doses of famotidine (3 and 10 mg/kg) or dicyclomine (45 mg/kg) significantly reduced total dyskinetic behavior |
| Cell Experiment | |
|---|---|
| Cell lines | |
| Preparation method | |
| Concentrations | |
| Incubation time | |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats |
| Formulation | 0.9% saline |
| Dosages | 16, 32, or 64 mg/kg |
| Administration | i.p. |
| Molecular Weight | 345.95 |
| Formula | C19H36ClNO2 |
| CAS Number | 67-92-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related AChR/AChE Products |
|---|
| Tacrine
Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate agent. |
| THRX-160209
THRX-160209 is a potent antagonist at the M(2) muscarinic acetylcholine (ACh) receptor subtype that was designed using a multivalent strategy, simultaneously targeting the orthosteric site and a nearby site known to bind allosteric ligands. |
| Catestatin
Catestatin is a 21-amino acid residue, cationic and hydrophobic peptide. |
| α-Conotoxin MII
α-Conotoxin MII (α-CTxMII), a 16-amino acid peptide from the venom of the marine snail Conus magus, potently blocks nicotinic acetylcholine receptors (nAChRs) composed of α3β2 subunits, with an IC50 of 0.5 nM. |
| COG 133 TFA
COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. |
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