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Diclofenamide (Dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-Disulfamoylbenzene class. It is used as an adjunct to reduce intraocular pressure in the research of glaucoma.
| Molecular Weight | 305.16 |
| Formula | C6H6Cl2N2O4S2 |
| CAS Number | 120-97-8 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Nakul Katyal, et al. Dichlorphenamide for Refractory Hyperkalemic Periodic Paralysis
[2] Jeffrey M Statland, et al. Review of the Diagnosis and Treatment of Periodic Paralysis
[3] Sarah L Greig. Dichlorphenamide: A Review in Primary Periodic Paralyses
[4] S Lindskog. Structure and mechanism of carbonic anhydrase
| Related Carbonic Anhydrase Products |
|---|
| Benzthiazide
Benzthiazide is a thiazide diuretic, promoting water loss from the body. |
| Ethoxzolamide
Ethoxzolamide is an inhibitor of the metalloenzyme carbonic anhydrase, which inhibits hCA I, hCA II, hCA IV, hCA VI and hCA VII with Ki of 25 nM, 8 nM, 93 nM, 43 nM and 0.8 nM, respectively. |
| Methyclothiazide
Methyclothiazide (MCTZ) is an orally active, substituted benzothiazide that also antagonizes extracellular voltage-dependent calcium channel (VDCC) activity. It can be used in the study of hypertension-related diseases. |
| U-104
U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM, respectively, very low inhibition for CA I and CA II. |
| Tioxolone
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. |
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