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DiaPep277

Cat. No. M31316
DiaPep277 Structure
Synonym:

DiaPep 277

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Biological Activity

DiaPep277 is a peptide containing 24 amino acids based on residues 437 to 460 of Heat Shock Protein 60 (HSP60) for studies related to the immune system in type 1 diabetes.

Chemical Information
Molecular Weight 2390.73
Formula C106H180N28O34
CAS Number 179822-83-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nanette C Schloot, et al. Clin Immunol. DiaPep277® and immune intervention for treatment of type 1 diabetes

[2] Dario Tuccinardi, et al. Expert Opin Biol Ther. DiaPep277 peptide therapy in the context of other immune intervention trials in type 1 diabetes

[3] Britta Fischer, et al. Expert Opin Biol Ther. Immunomodulation with heat shock protein DiaPep277 to preserve beta cell function in type 1 diabetes - an update

[4] Dana Elias, et al. Ann N Y Acad Sci. DiaPep277 preserves endogenous insulin production by immunomodulation in type 1 diabetes

[5] Nick Giannoukakis. Curr Opin Investig Drugs. DiaPep277 (DeveloGen)

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