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Desoxyrhapontigenin

Cat. No. M17184
Desoxyrhapontigenin Structure
Size Price Availability Quantity
5mg USD 105  USD105 In stock
10mg USD 180  USD180 In stock
20mg USD 300  USD300 In stock
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Biological Activity

Desoxyrhapontigenin

Chemical Information
CAS Number 33626-08-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Feng Liang, et al. AMB Express. Desoxyrhapontigenin attenuates neuronal apoptosis in an isoflurane-induced neuronal injury model by modulating the TLR-4/cyclin B1/Sirt-1 pathway

[2] Phuong Thao Tran, et al. Int J Mol Med. Desoxyrhapontigenin inhibits RANKL‑induced osteoclast formation and prevents inflammation‑mediated bone loss

[3] Stephanie C Casey, et al. Semin Cancer Biol. Cancer prevention and therapy through the modulation of the tumor microenvironment

[4] Ran Joo Choi, et al. Redox Biol. Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1 expression in macrophages and inflammatory lung injury

[5] Ran Joo Choi, et al. Int Immunopharmacol. Desoxyrhapontigenin, a potent anti-inflammatory phytochemical, inhibits LPS-induced inflammatory responses via suppressing NF-κB and MAPK pathways in RAW 264.7 cells

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