Desoxycorticosterone pivalate (DOCP) is a salt corticosteroid that may be used in studies related to primary hypoadrenocorticism (PH).
| Molecular Weight | 414.58 |
| Formula | C26H38O4 |
| CAS Number | 808-48-0 |
| Form | Solid |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Mineralocorticoid Receptor Products |
|---|
| Lorundrostat
Lorundrostat is an aldosterone synthase inhibitor and is used in studies related to hypertension. |
| LY2623091
LY2623091 is a salicorticoid receptor (MR) antagonist that may be used in studies related to chronic kidney disease and hypertension. |
| Ocedurenone
Ocedurenone is a novel nonsteroidal salicorticoid receptor (MR) antagonist that may be used in studies related to kidney disease. |
| Baxdrostat
Baxdrostat is a aldosterone synthase inhibitor. |
| Osilodrostat phosphate
Osilodrostat (LCI699) phosphate is a potent, orally active11β-hydroxylase (CYP11B1) inhibitor with an IC50 value of 35 nM. Osilodrostat phosphate is a potent, orally aldosterone synthase (CYP11B2) inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat phosphate inhibits aldosterone and corticosterone synthesis. |
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