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Mineralocorticoid Receptor Mineralocorticoid Receptor


Cat.No.  Name Information
M21053 Apararenone Apararenone is an oral nonsteroidal mineralocorticoid receptor (MR) antagonist.
M11399 AZD9977 AZD9977 is a potent, selective, and orally active modulator of corticosteroid receptors (MR). AZD9977 was studied for heart failure and chronic kidney disease.
M9957 Finerenone Finerenone (BAY 94-8862) is a third generation selective, oral active, non-steroidal halocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone showed good selectivity (>500-fold) compared to glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (AR). Finerenone has potential applications in the study of heart and kidney diseases, such as type 2 diabetes and chronic kidney disease.
M6558 Canrenone Canrenone is a mineralocorticoid receptor antagonist.
M5652 Fludrocortisone acetate Fludrocortisone Acetate is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body. It is used to treat Addison's disease by decreasing the amount of sodium that is lost (excreted) in your urine,also used to increase blood pressure.
M5233 Osilodrostat (LCI699) Osilodrostat (LCI699) is a potent inhibitor of human 11β -hydroxylase and aldosterone synthase with IC50 values of 2.5 and 0.7nM, respectively.
M3173 Potassium canrenoate Canrenoate potassium is a predrug for the release of Canrenone and an effective antagonist of competitive salt ocorticoid receptor. As a diuretic, Canrenoate potassium is used in the study of hypertension.
M3028 Spironolactone Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy.

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