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Deriglidole

Cat. No. M22182
Deriglidole Structure
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Biological Activity

Deriglidole

Chemical Information
Molecular Weight 255.36
Formula C16H21N3
CAS Number 122830-14-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] E Guillot, et al. Life Sci. Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole

[2] A Natali, et al. Am J Physiol. Effects of acute alpha 2-blockade on insulin action and secretion in humans

[3] E Guillot, et al. Life Sci. Involvement of capsaicin-sensitive nerves in the regulation of glucose tolerance in diabetic rats

[4] E Guillot, et al. Am J Physiol. Involvement of alpha 2-adrenoceptors in metabolic and hormonal responses to a mixed meal in beagle dogs

[5] E Guillot, et al. Life Sci. Alpha 2-adrenoceptors and the regulation of glucose, insulin and amylin levels in diabetic rats

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