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Dendrobine

Cat. No. M4718
Dendrobine Structure
Size Price Availability Quantity
20mg USD 315  USD350 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Dendrobine

Product Citations
Customer Product Validations & Biological Datas
Source Basic Clin Pharmacol Toxicol (2020), Figure 2, Dendrobine (AbMole Bioscience)
Method orally gavaged
Cell Lines 10-12-week-old C57BL/KsJ+/+ (wild-type) mice
Concentrations 20 mg/kg
Incubation Time 20 days
Results After 10 days of pregnancy, we performed glucose and insulin tolerance tests again on the same mice and found that, compared with wild-type mice, GDM mice displayed glucose tolerance and insulin resistance, which can be alleviated by dendrobine treatment
Source Basic Clin Pharmacol Toxicol (2020), Figure 1, Dendrobine (AbMole Bioscience)
Method orally gavaged
Cell Lines 10-12-week-old C57BL/KsJ+/+ (wild-type) mice
Concentrations 20 mg/kg
Incubation Time 20 days
Results Compared with the high and stable serum insulin level in the wild-type mice, the serum insulin level diminished during pregnancy in GDM mice, which was reversed in the GDM + dendrobine group
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number 2115-91-5
Purity >98%
Solubility
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dendrobine supplier, inhibitors

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