Free shipping on all orders over $ 500

Delpazolid

Cat. No. M6239
Delpazolid Structure
Synonym:

LCB01-0371

Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 320  USD320 In stock
50mg USD 1130  USD1130 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

In vitro: Delpazolid (LCB01-0371), at concentrations of 1×MIC and 2×MIC, has bacteriostatic activity against MSSA and MRSA after 24 h. At concentrations of 4×MIC and 8×MIC, Delpazolid shows bacteriostatic activity, but there is no regrowth at concentrations of 4×MIC and 8×MIC after 24 h of incubation. The survival of M. abscessus is greatly decreased in the presence of Delpazolid (LCB-0371) (MIC50=1.2 μg/mL). Delpazolid dramatically decreases the number of intracellular mycobacteria present at 2 days after infection at concentrations of 0.1, 1, and 10 μg/mL.

In vivo: When administered orally, Delpazolid (LCB01-0371) shows potent protective effects against systemic infections caused by Gram-positive and Gram-negative bacteria. Against infection caused by S. aureus Giorgio (MSSA), the ED50 of Delpazolid is 4.53 mg/kg of body weight. Against S. aureus p125 (MRSA), the ED50 of Delpazolid is 2.96 mg/kg. When Delpazolid (LCB-0371) is administered at 100 mg/kg daily (by gavage), the colony-forming unit (CFU) counts tend to be decreased in the lungs of mice at 7 days after infection.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time 2 days
Animal Experiment
Animal models WT mice
Formulation PBS
Dosages 2.96 mg/kg
Administration oral
Chemical Information
Molecular Weight 308.31
Formula C14H17FN4O3
CAS Number 1219707-39-7
Form Solid
Solubility (25°C) 30 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kim TS, et al. Antimicrob Agents Chemother. Activity of LCB01-0371, a Novel Oxazolidinone, against Mycobacterium abscessus.

[2] Jeong JW, et al. Antimicrob Agents Chemother. In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.

Related Antibiotic Products
Kendomycin

Kendomycin is a polyketide antibiotic with significant antibacterial activity and tumor cytotoxicity. At low concentrations (MIC: 5 μg/mL), Kendomycin inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA) strain COL. In addition, Kendomycin is an endothelin receptor antagonist and calcitonin receptor agonist.

Ceftobiprole

Ceftobiprole is a broad-spectrum cephalosporin with rapid bactericidal activity against Gram-positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains (MRSA), and Gram-negative bacteria, with a MIC90 value of 2 μg/mL against MRSA.

Showdomycin

Showdomycin is an antibiotic that is induced by IM-2 in Streptomyces.

Quinupristin

Quinupristin is a streptogramin antibiotic.

Buforin II

Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide.

  Catalog
Abmole Inhibitor Catalog




Keywords: Delpazolid, LCB01-0371 supplier, Antibiotic, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.