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Decylubiquinone

Cat. No. M22208
Decylubiquinone Structure
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Biological Activity

Decylubiquinone

Chemical Information
Molecular Weight 322.4
Formula C19H30O4
CAS Number 55486-00-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sujan Chatterjee, et al. Cell Signal. Protective role of Decylubiquinone against secondary melanoma at lung in B16F10 induced mice by reducing E-cadherin expression and ameliorating ROCKII-Limk1/2-Cofiliin mediated metastasis

[2] Jinlian Li, et al. Front Pharmacol. Decylubiquinone Inhibits Colorectal Cancer Growth Through Upregulating Sirtuin2

[3] Jinghua Cao, et al. Angiogenesis. Decylubiquinone suppresses breast cancer growth and metastasis by inhibiting angiogenesis via the ROS/p53/ BAI1 signaling pathway

[4] Jayne E Telford, et al. J Biol Chem. Decylubiquinone increases mitochondrial function in synaptosomes

[5] Leonardo Borges Murad, et al. Biofactors. Effects of decylubiquinone (coenzyme Q10 analog) supplementation on SHRSP

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