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Decoquinate

Cat. No. M2616
Decoquinate Structure
Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 65  USD65 In stock
500mg USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

Decoquinate is a coccidiostat.

Chemical Information
Molecular Weight 417.54
Formula C24H35NO5
CAS Number 18507-89-6
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sumei Zeng, et al. Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria

[2] No authors listed. Efficacy of the feed additive consisting of decoquinate (Deccox ®) for use in chickens for fattening (Zoetis Belgium SA)

[3] No authors listed. Safety and efficacy of Deccox ® (decoquinate) for chickens for fattening

[4] Małgorzata Olejnik, et al. Deposition and depletion of decoquinate in eggs after administration of cross-contaminated feed

[5] M A Taylor, et al. The history of decoquinate in the control of coccidial infections in ruminants

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