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Dazoxiben hydrochloride

Cat. No. M9446
Dazoxiben hydrochloride Structure
Synonym:

Dazoxiben HCl; UK-37248

Size Price Availability Quantity
10mg USD 162  USD180 In stock
25mg USD 333  USD370 In stock
50mg USD 594  USD660 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production. In vivo, Dazoxiben (100 μg/kg, intraperitoneal administration) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 268.7
Formula C12H13ClN2O3
CAS Number 74226-22-5
Purity >99%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
References

Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor.
Yu SM, et al. Br J Pharmacol. 1994 Mar;111(3):906-12. PMID: 8019768.

Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.
Patrignani P, et al. J Pharmacol Exp Ther. 1984 Feb;228(2):472-7. PMID: 6537977.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dazoxiben hydrochloride, Dazoxiben HCl; UK-37248 supplier, Prostaglandin Receptor, inhibitors

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