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Darutigenol

Cat. No. M16504
Darutigenol Structure
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Biological Activity

Darutigenol

Chemical Information
CAS Number 5940-00-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] XiaoXu Gao, et al. Bioorg Chem. ent-Pimarane diterpenoids from Siegesbeckia glabrescens with anti-inflammatory activity

[2] Li-Juan Gao, et al. Zhongguo Zhong Yao Za Zhi. [Diterpenoids as PPARγ agonists from Siegesbeckia pubescens and their anti-inflammatory effects in vitro]

[3] Jianbin Wang, et al. J Nat Prod. ent-Strobane and ent-Pimarane Diterpenoids from Siegesbeckia pubescens

[4] Linan Huo, et al. J Sep Sci. Simultaneous determination of seven major diterpenoids in Siegesbeckia pubescens Makino by high-performance liquid chromatography coupled with evaporative light scattering detection

[5] Phan Minh Giang, et al. Chem Pharm Bull (Tokyo). ent-pimarane-type diterpenoids from Siegesbeckia orientalis L

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