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Dantrolene sodium hemiheptahydrate

Cat. No. M5550
Dantrolene sodium hemiheptahydrate Structure

Dantrolene sodium salt, Dantrium, Sodium dantrolene

Size Price Availability Quantity
100mg USD 90 In stock
500mg USD 280 In stock
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Biological Activity

Dantrolene sodium hemiheptahydrate ia a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 399.29
Formula C14H9N4O5.7/2H2O.Na
CAS Number 24868-20-0
Purity 99.45%
Solubility 12 mg/mL in DMSO
Storage at -20°C

Muscle relaxant action of dantrolene sodium in rats.
Saito S, et al. Res Commun Chem Pathol Pharmacol. 1993 Sep;81(3):345-54. PMID: 8235068.

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Keywords: Dantrolene sodium hemiheptahydrate, Dantrolene sodium salt, Dantrium, Sodium dantrolene supplier, Calcium Channel, inhibitors

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