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Danazol

Cat. No. M3933
Danazol Structure
Synonym:

Danocrine, NSC 270916

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Danazol is a synthetic gonadotropin inhibitor which has a preventive effect on estrogen -related endometrial carcinogenesis in mice. Danazol therapy has also shown regression of established mammary carcinoma in rats. Danazol prevents ovulation by suppressing the increase of luteinizing hormone during the middle of the menstrual cycle. Danazol inhibits ovarian steroidogenesis resulting in decreased secretion of estradiol and may increase androgens. Danazol displaces testosterone from sex hormone-binding globulin (SHBG), displacing it and increasing serum testosterone levels. Danazol also directly stimulates androgen and progesterone receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 337.46
Formula C22H27NO2
CAS Number 17230-88-5
Purity >98%
Solubility chloroform 25 mg/ml
Storage at -20°C
References

[1] Floyd WS. Int J Fertil. Danazol: endocrine and endometrial effects.

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Keywords: Danazol, Danocrine, NSC 270916 supplier, inhibitors

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