Free shipping on all orders over $ 500

Dalfopristin

Cat. No. M6129
Dalfopristin Structure
Synonym:

RP54476

Size Price Availability Quantity
1mg USD 260 In stock
5mg USD 860 In stock
10mg USD 1500 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Quinupristin/Dalfopristin(Q/D) is a combination of streptogramins B (Quinupristin) and streptogramins A (Dalfopristin) at 30:70 ratio. Quinupristin/Dalfopristin, a semisynthetic injectable streptogramin, is a combination of 2 synergistic antibiotic components that are derived from pristinamycin: a type B streptogramin (Quinupristin) and a type A streptogramin (Dalfopristin), in a 30:70 weight-to-weight ratio.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Eighteen New Zealand white rabbits
Formulation 5% dextrose water
Dosages 100 mg/mL
Administration i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 690.85
Formula C34H50N4O9S
CAS Number 112362-50-2
Purity >98%
Solubility 30 mg/mL in DMSO
Storage at -20°C
References

Genetic features of livestock-associated Staphylococcus aureus ST9 isolates from Chinese pigs that carry the lsa(E) gene for quinupristin/dalfopristin resistance.
Yan X, et al, Int J Med Microbiol. 2016 Dec;306(8):722-729. PMID: 27528592.

Safety of intravitreal quinupristin/dalfopristin in an animal model.
Giordano VE, et al. Int J Ophthalmol. 2016 Mar 18;9(3):373-8. PMID: 27158605.

Related Products
VH-298

VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, with a Kd value of 80 to 90 nM.

6-Methylcoumarin

6-Methylcoumarin belongs to the class of organic compounds known as coumarins and derivatives.

BTTAA

BTTAA is a Cu(I)-stabilizing ligand, whch performs potently with ubiquitin Glu18AzF.

Ezutromid

Ezutromid (also known as BMN-195 and SMT C1100) is a first orally bioavailable utrophin's translation modulator with EC50 of 0.4 uM.

GNE-495

GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Dalfopristin, RP54476 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.