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Dalasetron Mesylate hydrate

Cat. No. M5548
Dalasetron Mesylate hydrate  Structure
Size Price Availability Quantity
100mg USD 180 In stock
200mg USD 290 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Dolasetron(MDL-73147) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 438.49
Formula C20H26N2O7S
CAS Number 878143-33-0
Purity >99%
Solubility 39 mg/mL in DMSO
Storage at -20°C
References

Sulfonate salts of the therapeutic agent dapsone: 4-[(4-aminophenyl)sulfonyl]anilinium benzenesulfonate monohydrate and 4-[(4-aminophenyl)sulfonyl]anilinium methanesulfonate monohydrate.
Gaytán-Barrientos NS, et al. Acta Crystallogr C Struct Chem. 2016 Apr;72(Pt 4):280-4. PMID: 27045177.

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  Catalog
Abmole Inhibitor Catalog 2017




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