DAB (3,3' Diaminobenzidine Tetrahydrochloride) is an organic compound that is both chemically and thermodynamically stable; DAB has been used in immunohistochemical staining of nucleic acids and proteins.
Oxid Med Cell Longev. 2023 Jan 14;2023:6896790.
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DAB purchased from AbMole
| Molecular Weight | 360.11 |
| CAS Number | 7411-49-6 |
| Solubility (25°C) | Water 60 mg/mL DMSO ≥ 43 mg/mL |
| Storage | 2-8°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Gustaw Mazurek. Sensors (Basel). DAB Signal Preprocessing for Passive Coherent Location
[5] F M Foss. Clin Lymphoma. DAB(389)IL-2 (ONTAK): a novel fusion toxin therapy for lymphoma
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