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D-Altrose

Cat. No. M22137
D-Altrose Structure
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50mg USD 225  USD225 In stock
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Biological Activity

D-Altrose

Chemical Information
Molecular Weight 180.16
Formula C6H12O6
CAS Number 1990-29-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Noelia Arajo, et al. Org Lett. Synthesis from D-altrose of (5R,6R,7R,8S)-5,7-dihydroxy-8-hydroxymethylconidine and 2,4-dideoxy-2,4-imino-D-glucitol, azetidine analogues of swainsonine and 1,4-dideoxy-1,4-imino-D-mannitol

[2] Masakuni Tako, et al. Carbohydr Res. Identification of rare 6-deoxy-D-altrose from an edible mushroom (Lactarius lividatus)

[3] Yuji Watanabe, et al. Acta Crystallogr Sect E Struct Rep Online. β-d-Altrose

[4] Stefano Bresciani, et al. Chem Commun (Camb). Fluorosugars: synthesis of the 2,3,4-trideoxy-2,3,4-trifluoro hexose analogues of D-glucose and D-altrose and assessment of their erythrocyte transmembrane transport

[5] Buetusiwa Thomas Menavuvu, et al. J Biosci Bioeng. Novel substrate specificity of D-arabinose isomerase from Klebsiella pneumoniae and its application to production of D-altrose from D-psicose

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