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Cyproheptadine hydrochloride sesquihydrate

Cat. No. M5543
Cyproheptadine hydrochloride sesquihydrate Structure
Size Price Availability Quantity
100mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Cyproheptadine hydrochloride sesquihydrate is an antihistamine and is an antagonist of serotonin and histamine2.

Chemical Information
Molecular Weight 350.88
Formula C21H21N . 3/2H2O . HCl
CAS Number 41354-29-4
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yoichi Tanikawa, et al. Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions

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