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CVT-10216

Cat. No. M3706

CVT-10216 Structure
Size Price Availability Quantity
5mg USD 180 In stock
10mg USD 270 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

CVT-10216 counteracted anxiety in all models except that produced by the 5-HT(2C) agonist, mCPP. CVT-10216 exhibited both acute and prophylactic inhibitions of repeated alcohol-withdrawal-induced anxiety. CVT-10216 increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents, including deprivation-induced drinking. CVT-10216 also prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking even when alcohol is not available (i.e., no acetaldehyde). CVT-10216 prevents alcohol-induced increases in NAc DA without changing basal levels. CVT-10216 does not show rewarding or aversive properties in the CPP paradigm at therapeutic doses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 465.48
Formula C24H19NO7S
CAS Number 1005334-57-5
Purity >99%
Solubility DMSO
Storage at -20°C
References

A selective ALDH-2 inhibitor reduces anxiety in rats.
Overstreet DH, et al. Pharmacol Biochem Behav. 2009 Dec;94(2):255-61. PMID: 19747934.

Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor.
Arolfo MP, et al. Alcohol Clin Exp Res. 2009 Nov;33(11):1935-44. PMID: 19673742.

CVT-10216 selectively suppresses binge eating of palatable foods and attenuates dopamine release in the accumbens of rats
Miriam E Bocarsly, et al. The FASEB Journal. 2012;26:1012.3.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CVT-10216 supplier, ALDH, inhibitors

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