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Curvularin

Cat. No. M8411

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Curvularin Structure

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Quality Control & Documentation
Biological Activity

S - Curvularin is a macrocyclic lactone with cytotoxic activity. Curvularin inhibits cell division as well as expression of human inducible nitric oxide synthase (iNOS), an enzyme critically involved in pro-inflammatory immune processes. Curvularin anti-inflammatory activity was demonstrated in chronic inflammatory disease models in mice such as Chronic Induced Arthritis (CIA) as well as in human alveolar epithelial A549/8 cells.

Chemical Information
Molecular Weight 292.33
Formula C16H20O5
CAS Number 10140-70-2
Solubility (25°C) DMSO: 1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rajkiran Reddy Banala, et al. The Anti-Inflammatory and Cytoprotective Efficiency of Curvularin, a Fungal Macrolactone against Lipopolysaccharide-Induced Inflammatory Response in Nucleus Pulposus Cells: An In Vitro Study

[2] Srinivasa Rao Allu, et al. A Unified Synthetic Approach to Optically Pure Curvularin-Type Metabolites

[3] Xuewei Ye, et al. A new curvularin glycoside and its cytotoxic and antibacterial analogues from marine actinomycete Pseudonocardia sp. HS7

[4] Ling-Hong Meng, et al. Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa

[5] Jixun Zhan, et al. Microbial transformation of curvularin

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Keywords: Curvularin supplier, inhibitors, activators

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