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CP 640186

Cat. No. M3149
CP 640186 Structure
Size Price Availability Quantity
2mg USD 72  USD80 In stock
5mg USD 108  USD120 In stock
10mg USD 175.5  USD195 In stock
50mg USD 675  USD750 In stock
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Quality Control
Biological Activity

CP-640186 is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. CP-640186 inhibites fatty acid synthesis in rats, CD1 mice, and ob/ob mice with ED50s of 13, 11, and 4 mg/kg, and stimulated rat whole body fatty acid oxidation with an ED50 of ~30 mg/kg.

Product Citations
Customer Product Validations & Biological Datas
Source Am J Cancer Res 2020 Feb. Figure 4. CP-640186 (Abmole Bioscience, USA)
Method Western blot
Cell Lines ANGPTL4-/- mice
Concentrations -
Incubation Time -
Results Another reagent (CP-640186), an ACC1 inhibitor, also decreased the TNF-α and CD86 levels of ANGTPL4-/- macrophages to normal levels.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 485.62
Formula C30H35N3O3
CAS Number 591778-68-6
Purity 99.46%
Solubility DMSO 10 mM
Storage at -20°C
References

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals.
Harwood HJ Jr, et al. J Biol Chem. 2003 Sep 26;278(39):37099-111. PMID: 12842871.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CP 640186 supplier, inhibitors

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