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Coronarin E

Cat. No. M16506
Coronarin E Structure
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Coronarin E

Chemical Information
CAS Number 117591-81-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Santhi Subramanyan, et al. Chem Biol Drug Des. Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe

[2] Minyi Tian, et al. Front Pharmacol. Phytochemical Analysis, Antioxidant, Antibacterial, Cytotoxic, and Enzyme Inhibitory Activities of Hedychium flavum Rhizome

[3] Takahiro Miyake, et al. Chem Pharm Bull (Tokyo). Concise syntheses of coronarin A, coronarin E, austrochaparol and pacovatinin A

[4] Ioannis Margaros, et al. J Org Chem. Synthesis of chinensines A-E

[5] M Jung, et al. J Nat Prod. A concise conversion of (-)-sclareol into (+)-coronarin E and (-)-7-epi-coronarin A

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