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Cobicistat

Cat. No. M2537
Cobicistat  Structure
Synonym:

GS-9350

Size Price Availability Quantity
10mg USD 270  USD270 In stock
50mg USD 690  USD690 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 776.02
Formula C40H53N7O5S2
CAS Number 1004316-88-4
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Lianhong Xu, et al. ACS Med Chem Lett. Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer

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Rhapontigenin

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(Rac)-Brassinazole

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Stiripentol is an LDH inhibitor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cobicistat , GS-9350 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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